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In the turbulent era of Japan's Bakumatsu period, Osaka buzzes with scholars and ambition, and young doctor Tōma Matsuzaki stands at the crossroads of tradition and innovation. Driven by an insatiable curiosity, Tōma studies the cutting-edge medical techniques of the Hanaoka school, wielding both scalpel and sword with equal skill. As he confronts the challenges of a society in flux, Tōma's journey becomes a quest to heal not just bodies but also the wounds of a nation on the brink of change.