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Takahashi Tetsuo is a high school biology teacher fascinated by demi-humans, or "demis," beings like vampires, succubi, and dullahans who differ slightly from humans. When he meets Hikari, a lively vampire; Kyoko, a shy dullahan; and Yuki, a timid snow girl—all students at his school—he’s thrilled to learn more about them. Alongside these girls and their succubus teacher, Sakie, Tetsuo explores their unique traits and challenges, helping them navigate their lives as demis in a human world.