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A mysterious creature, capable of Mach 20 speeds, destroys most of the moon and threatens to annihilate Earth in a year unless stopped. This being becomes the homeroom teacher of Class 3-E at Kunugigaoka Junior High, tasking the students with assassinating him before the deadline. Nagisa Shiota, a quiet student with a knack for observation, and his classmates, each with unique skills, devise creative plans to kill their teacher, whom they nickname Koro-sensei. Despite his deadly reputation, Koro-sensei proves to be a caring educator, guiding the students in academics and assassination techniques. The class navigates school life, training, and their bizarre mission, forming unexpected bonds with their seemingly indestructible target.