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A red blood cell works to complete deliveries inside a human body. Her route is constantly disrupted by threats such as strep throat, hay fever, and influenza. A white blood cell and other specialized cells help defend the body and keep it functioning. Platelets, killer T cells, neurons, and many others each have jobs tied to health. Immune responses become workplace comedy and action as every cell tries to keep the body alive.

Nagi Umino, a diligent high school student, discovers he was switched at birth and is set to meet his biological family. On the way, he crosses paths with Erika Amano, a popular internet celebrity desperate to avoid an arranged marriage, who ropes him into pretending to be her boyfriend. To their shock, Nagi and Erika learn they are the babies swapped at birth—and their parents, unwilling to part with the children they raised, decide to arrange their marriage. Forced into an engagement and living together, Nagi, who has feelings for his classmate Hiro, and Erika, determined to forge her own path, navigate a whirlwind of emotions, rivalries, and unexpected bonds.